EXPERIMENTAL GLOMERULONEPHRITIS AND IGAN.

Mohamed DAHA (Leiden; Netherlands)

DEVELOPMENT OF SPONTANEOUS IgA NEPHROPATHY IN TRANSGENIC MICE EXPRESSING MUTATED CD89 THAT CANNOT ASSOCIATE WITH THE FcR g .

Michelle ARCOS-FAJARDO, Ivan C. MOURA, Michel PEUCHMAUR, Renato C. MONTEIRO. INSERM E-0225, Bichat Medical School and Robert-Debre Hospital, Paris, France.

ROLE OF FC a RI/CD89 RECEPTOR IN AN EXPERIMENTAL MOUSE MODEL FOR IGA NEPHROPATHY?

Paul J.M. VAN DER BOOG*, Cees VAN KOOTEN*, Ger VAN ZANDBERGEN*, Ngaisah KLAR-MOHAMAD*, Beatrijs OORTWIJN*, Nico A. BOS***, Alexandra VAN REMOORTERE**, Cornelis H. HOKKE**, Johan W. DE FIJTER*, Mohamed R. DAHA*. *Department of Nephrology and **Parasitology, Leiden University Medical Center, "Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

CD89 CROSS-LINKING DETERIORATES ANTI-GBM MEDIATED GLOMERULAR INJURY IN CD89 TRANSGENIC MICE.

Yutaka KANAMARU, Toshinao TSUGE, Michelle ARCOS-FAJARDO, Benoit PASQUIER, Elie HADDAD, Ulrich BLANK, Yasuhiko TOMINO, Renato C. MONTEIRO. INSERM E0225, Bichat Medical School, Paris 75870, France ; and Division of Nephrology, Department of Medecine, Jutendo University, School of Medicine, Tokyo, Japan.

IgA NEPHROPATHY IS A COMMON DISEASE IN MARMOSETS AND SHOWS HOMOLOGY TO THE HUMAN DISEASE.

Frank EITNER, Tammo OSTENDORF, Masashi KITAHARA, Susanne RENSING, Petra HOFMANN, Kerstin MAETZ-RENSING, Franz-Josef KAUP, Hermann-Josef GRONE, Jürgen FLOEGE. Division of Nephrology and Immunology, University of Aachen, Germany ; German Primate Center, DPZ Göttingen, Germany ; German Cancer Research Institute, DKFZ Heidelberg, Germany.

MURINE IgA NEPHROPATHY IS LINKED TO HUMAN IGAN1, LOCATED CHROMOSOME 6q22-23.

Hitoshi SUZUKI, Yusuke Suzuki , Takahiro Yamanaka , Satoshi Horikoshi , and Yasuhiko Tomino . Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.

SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY IgG AND IgA-IMMUNE COMPLEXES IN CULTURED MESANGIAL CELLS.

Carmen GOMEZ-GUERRERO, Oscar LOPEZ-FRANCO, Purificacion HERNANDEZ-VARGAS, Guillermo SANJUAN, Guadalupe ORTIZ-MUNOZ, Yusuke SUZUKI, Jesus EGIDO. Renal and Vascular Research Lab. Fundacion Jimenez Diaz. Autonoma University. Madrid. Spain.

PDGF-INDUCED DIFFERENTIAL GENE EXPRESSION IN CULTURED HUMAN MESANGIAL CELLS.

Jan NOVAK 1, Mark CARPENTER 2 , Stacy HALL 1 , Zdenek NOVAK 1 , Rhubell BROWN 1 , Huong L. VU 1 , Richard MAYNE 1 , Bruce A. JULIAN 1 , Jiri MESTEKY 1 , Milan TOMANA 1 . 1 University of Alabama at Birmingham, Birmingham AL 35294, USA. ; 2 Auburn University, Auburn, AL 26849, USA.

ROLE OF MESANGIAL IGA RECEPTORS IN IGAN.

Renato MONTEIRO (Paris; France)

CHARACTERISATION OF AN Fc ALPHA/MU RECEPTOR SPLICE VARIANT.

Kenneth J. MCDONALD, Janet M. ALLEN, Jan NOVAK 1 , Lea NOVAK 1 & Alan G. JARDINE. Renal Unit, Western Infirmary, Glasgow, UK & 1 Dept of Microbiology, University of Alabama at Birmingham, Birmingham AL, USA.

BINDING CHARACTERISTICS OF MONOMERIC IgA TO THE MYELOID Fc a R/CD89.

Beatrijs D. OORTWIJN, Paul J.M. VAN DER BOOG, Anja ROOS, Ngaisah KLAR-MOHAMAD, Alexandra VAN REMOORTERE*, Cornelis H. HOKKE*, Mohamed R. DAHA, Cees VAN KOOTEN. Dept. Nephrology, Parasitology*, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

TRANSFERRIN RECEPTOR AND Fca/µ RECEPTOR ARE NOT THE MAJOR IGA1 RECEPTOR ON HUMAN MESANGIAL CELLS.

R-H HU, Ming-Hai ZHAO, Y-K ZHANG, H-Y WANG. Institute of Nephrology, Peking University First Hospital, Beijing 100034, PR. China.

SigA SHOWS A STRONG BINDING TO HUMAN MESANGIAL CELLS AND IS DEMONSTRATED IN HIGH MOLECULAR WEIGHT FRACTIONS OF CIRCULATING SERUM IgA.

Beatrijs D. OORTWIJN, Anja ROOS, Paul J.M. VAN DER BOOG, Mohamed R. DAHA, Cees VAN KOOTEN. Dept. Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

SIZE AND O-LINKED SUGARS OF IgA1 ARE INVOLVED IN IgA1 INTERACTION WITH MESANGIAL TRANSFERRIN RECEPTOR IN IgA NEPHROPATHY.

Charlotte SADAKA, Ivan C. MOURA, Michelle ARCOS-FAJARDO, Valérie LEROY, Jan NOVAK, Marc BENHAMOU, Elie HADDAD, Koteswara R. CHINTALACHARUVU, Renato C. MONTEIRO. INSERM E0225, Bichat Medical School and Robert-Debré Hospital, Paris 75870, France ; University of Alabama at Birmingham and UCLA, USA.

PERIPHERAL BLOOD B CELL SUBSETS IN IgA NEPHROPATHY.

Jonathan BARRATT, Arvind BATRA, Karen MOLYNEUX, John FEEHALLY, and Alice C. SMITH. John Walls Renal Unit, Leicester General Hospital and Dept of Infection, Immunity and Inflammation, University of Leicester, United Kingdom.

DENDRITIC CELLS OF IGA NEPHROPATHY PATIENTS SHOW A REDUCED CAPACITY TO INDUCE IGA SWITCH IN NAIVE B CELLS.

Jan-Willem EIJGENRAAM, Johan W. DE FIJTER, Sylvia W.A. KAMERLING, Mohamed R. DAHA, Leendert C. PAUL, Cees VAN KOOTEN. Dept of Nephrology, LUMC, Leiden, The Netherlands.

ABNORMALITIES OF IGA1 PRODUCTION IN IGAN.

Alice C. SMITH (Leicester; U.K.)

ANALYSIS OF IgA1-1 O-LINKED GLYCANS: IMPLICATIONS FOR IgA NEPHROPATHY (IgAN).

Jan NOVAK 1, Matthew B. RENFROW 2 , Helen J. COOPER 3 , Milan TOMANA 1 , Landon WILSON 1 , Marion KIRK 1 , Rose KULHAVY 1 , Mogens KILIAN 4 , Knud POULSEN 4 , Yoshiyuki HIKI 5 , Kazunori TOMA 6 , Bruce A. JULIAN 1 , Stephen BARNES 1 , Mark R. EMMETT 2 , Alan G. MARSHALL 2 , Jiri MESTECKY 1 . 1 University of Alabama at Birmingham, Birmingham, AL 35294, USA; 2 National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA; 3 School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; 4 Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark; 5 Division of Nephrology, Department of Medicine, Fujita Health University, School of Medicine, Toyoake, Japan; 6 Research Department, The Noguchi Institute, Tokyo, Japan.

PROPERTIES AND INTERACTIONS OF CIRCULATING IMMUNE COMPLEXES (CIC) FROM IgA NEPHROPATHY (IgAN) PATIENTS WITH MESANGIAL CELLS (MC).

Milan TOMANA 1, Jan NOVAK 1, Karel MATOUSOVIC 1,2, Zdenek NOVAK 1, Rhubell BROWN 1, Stacy HALL 1, Lea NOVAK 1, Bruce A. JULIAN 1, Robert J. WYATT 3, Jiri MESTEKY 1 . 1 University of Alabama at Birmingham, Birmingham AL; 2 Charles Univ., Prague, Czech Republic; 3 Children's Fdn. Res. Ctr. at the Le Bonheur Children's Med. Ctr. Memphis, TN.

LOCALIZATION OF ANTIGENIC DETERMINANTS ON GALACTOSE-DEFICIENT IgA1 RECOGNIZED BY IgG ANTIBODIES.

Jiri MESTECKY 1, Rose KULHAVY 1, Milan TOMANA 1, Rhubell BROWN 1, Mogens KILIAN 4, Knud POULSEN 4, Bruce A. JULIAN 1, Jan NOVAK 1 . 1 University of Alabama at Birmingham, Birmingham, AL 35294, USA; 2 Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark.

ANALYSIS OF IGA1 O-GLYCOFORMS IN PRIMARY AND HEPATIC IMMUNOGLOBIN A NEPHROPATHY.

Shideh POURIA 1, Edward Tarelli 2, Stephen J Challacombe 3, Bruce M. Hendry 1 . 1 Department of Renal Medecine, GKT School of Medicine, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK; 2 Medical Biomics Centre, St Georges Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK; 3 Department of Oral Medicine, GKT School of Medicine, 28 th Floor, Guy's Tower, Guy's Hospital, St Thomas' Street, London SE1 9RT, UK.

IgA1-CONTAINING IMMUNE COMPLEXES (IC) ARE PRESENT IN THE URINE OF IgA NEPHROPATHY (IgAN) PATIENTS.

Karel MATOUSOVIC 1,2, Rose KULHAVY 1, Rhubell BROWN 1, Stacy HALL 1, Milan TOMANA 1, Jan NOVAK 1, Karel KONECNY 3, Bruce A. JULIAN 1, Jiri MESTECKY 1 . 1 University of Alabama at Birmingham, Birmingham, AL 35294, USA; 2 Charles University, Prague, Czech Republic; 3 University Hospital, Olomouc, Czech Republic.

b -1,3-GALACTOSYLTRANSFERASE ACTIVITY IN IgA NEPHROPATHY.

Katharine S BUCK, Jonathan BARRATT, John FEEHALLY, Alice C SMITH. John Walls Renal Unit, Leicester General Hospital and Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

ADVANCES IN ANALYSIS OF MESANGIAL IMMUNE COMPLEXES (IC) IN IgA NEHPROPATHY (IgAN) USING HIGH RESOLUTION IMAGING TECHNIQUE.

Lea NOVAK, Albert TOUSSON, Kent T. KEYSER, Jan Novak, Jiri MESTECKY, Bruce A. JULIAN. University of Alabama at Birmingham, Birmingham, AL 35294, USA.

POLYMORPHISMS IN THE GENE CODING FOR THE CORE1 B 1,3-GALACTOSYLTRANSFERASE T1 CONTRIBUTE TO THE GENETIC SUSCEPTIBILITY TO IGA NEPHROPATHY.

Doroti PIRULLI*, Sheila ULIVI*, Cristina ZADRO*, Sara BERTOK*, Sergio CROVELLA*, Francesco SCOLARI^, Marina FORAMITTI^, Paolo RAVANI +, Dario ROCCATELLO #, Silvana SAVOLDI°, Giuseppina CERULLO §, Luigi BISCEGLIA £, Leopoldo ZELANTE £, Jürgen FLOEGE'', Peter R. MERTENS'', Klaus ZERRES'', Efstathios ALEXOPOULOS &, Dimitrios KIRMIZIS & , Gian M. GHIGGERI l , Giovanni FRASCA g , Francesco P SCHENA § , and Antonio AMOROSO*. *Genetics Service - IRCCS Burlo Garofolo and "Dipartimento di Scienze delle Riproduzione e dello Sviluppo, University of Trieste, Italy; Renal Unit, Spedali Civili, Brescia, Italy; + Istituti Ospitalieri, Cremona, Italy; # Department of "Medicina e Oncologia Sperimentale", University of Torino, Torino, Italy; °Renal Unit Cattinara Hospital, Trieste, Italy; § Renal Unit, University of Bari, Italy; £ Genetic Unit, IRCCS Casa del Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy; "Division of Nephrology and Immunology, Institute of Genetics, University of Aachen, Germany; & Renal Unit, Aristotelian University of Thessaloniki, Greece, l Renal Unit, Ospedale Gaslini, Genova, Italy, g Renal Unit, University of Bologna, Italy.

IDENTIFICATION OF A CANDIDATE GENE FOR CMP-NeuAc:GalNac-IgA1 a 2, 6-SIALYLTRANSFERASE IN AN IgA1-PRODUCING CELL LINE.

Milan RASKA, Zina MOLDOVEANU, Judit ANDRASI, Rhubell BROWN, Stacy HALL, Rose KULHAVY, Milan TOMANA, Bruce JULIAN, Jan NOVAK, Jiri MESTECKY. University of Alabama at Birmingham, Birmingham, AL 35294, USA.

CONNECTIVE TISSUE GROWTH FACTOR (CTGF) IS ENHANCED IN CULTURED MESANGIAL CELLS BY ABERRANTLY GLYCOSYLATED IgA: POSSIBLE DIRECT ROLE OF MESANGIAL DEPOSIT OF IgA IN PROGRESSION OF IgA NEPHROPATHY.

Alessandro AMORE, S. TURCATO, L. GHISELLINI, M. CHIESA, P. CIRINA, G. CONTI, L. PERUZZI, R. COPPO. Divisione Nefrologia, Dialisi Trapianto - Ospedale Regina margherita. Piazza Polonia, 94 10126 Torino. Italy.

ROLE OF TRANSCRIPTIONAL FACTORS AND PROTEASOME ACTIVITY.

Rosanna COPPO (Torino, Italy)

INCREASED SYSTEMIC HOMING CD4 T CELLS IN IgA NEPHROPATHY.

Jonathan BARRATT, Arvind BATRA, Karen MOLYNEUX, John FEEHALLY and Alice C. SMITH. John Walls Renal Unit, Leicester General Hospital and Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

GLOMERULAR ACTIVATION OF THE LECTIN PATHWAY OF COMPLEMENT IN IgA NEPHROPATHY IS ASSOCIATED WITH A MORE SEVERE DISEASE.

Anja ROOS 1, Maria Pia RASTALDI 2, Marc A. SEELEN 1, Jan Willem EIJGENRAAM 1, Beatrijs D. OORTWIJN 1, Daniëlle J. VAN GIJLSWIJK-JANSSEN 1, Maria C. FABER-KROL 1, Novella CALVARESI 2, Misao MATSUSHITA 3, Teizo FUJITA 4, Cees VAN KOOTEN 1 , and Mohamed R. DAHA 1 . 1 Department of Nephrology, LUMC, Leiden, the Netherlands, 2 Renal Immunopathology Center, Milan, Italy, 3 Institute of Glycotechnology, Tokai University, Hiratsuka, Japan, and 4 Department of Biochemistry, Fukushima Medical University, Fukushima, Japan.

URINARY EXCRETIONS OF IL-6, TGF- b 1, TNF- a AND a 1-MICROGLOBULIN ARE INCREASED IN MILD AND CLINICALLY SILENT IgAN.

Virpi RAUTA, Anna-Maija TEPPO, Tom TORNROTH, Eero HONKANEN and Carola GRONHAGEN-RISKA. Helsinki University Central Hospital, department of Medicine, Division of Nephrology, Helsinki, Finland.

HISTOLOGICAL LESIONS AS PREDICTORS FOR THE EFFECTIVENESS OF STEROID THERAPY IN IGA NEPHROPATHY; UNI-AND MULTIVARIATE ANALYSIS ON 275 ADULT PATIENTS.

Kensuke JOH , Takeshi Nakazato, Satoshi Suzuki. Division of Clinical Investigation, Sakura National Hospital, 2-36-2, Ebaradai, Sakura-city, Chiba, 285-8765, Japan.

Glomerular Basement Membrane (GBM) thickness measurement on first renal biopsy (diagnosis) in IgA nephropathy (IGAN) is a major parameter in evaluating progression of the disease : thin GBM is propective.

François BERTHOUX, Carole DeprEle, Aïda Afiani, Blandine Laurent, Eric Alamartine. Nephrology Department, University North Hospital, 42055 Saint-Etienne Cédex 2, France.

ACTIVE TUBULITIS AND TUBULO-INTERSTITIAL NEPHRITIS IN PROGRESSIVE IgA NEPHROPATHY.

Leendert A. VAN ES 1, Emile DE HEER 2, Cees VAN KOOTEN 1, Annemiek M. VAN DER WAL 2, Marko J. MALLAT 1, Ingeborg M. BAJEMA 2, Jan A. BRUIJN 2, Johan W. DE FIJTER 1. Departments of Nephrology 1 and Pathology 2 , Leiden University Medical Center, LEIDEN, The Netherlands.

PROGRESSION TO END STAGE RENAL FAILURE IN PATIENTS WITH IGA NEPHROPATHY AND SECONDARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS.

Louise GIBLIN 1, George J. MELLOTTE 1, Collette MURPHY 2, Eoin F. GAFFNEY 2, and Brian KEOGH 1. 1 Department of Renal Medicine, The Adelaide & Meath Hospital, Dublin 24, Ireland and 2 Department of Histopathology, St. James Hospital, Dublin 8, Ireland.

RISK FACTORS FOR PROGRESSION IN IGAN.

Judit NAGY (Pecs; Hungary)

A CLINICOPATHOLOGIC STUDY OF 757 CASES OF CHINESE ADULT IGA NEPHROPATHY.

Gan LIU, Jianqing Jiang, Wanzhong Zou, Haiyan Wang. Renal Department, First Hospital, Peking University, Beijing, China, 100034.

RELATIONSHIP BETWEEN COMPONENTS OF PROTEINURIA, HISTOLOGICAL LESIONS AND PROGRESSION TO CHRONIC RENAL FAILURE IN IgA NEPHROPATHY (IgAN).

Claudio BAZZI, C. PETRINI°, V. RIZZA°, M. PAPARELLA, P. NAPODANO, B. RAVASI, D. CASELLATO, G. D'AMICO. Division of Nephrology and Dialysis, °Biochemical Laboratory, San Carlo Borromeo Hospital; Milan, Italy.

A FAMILY HISTORY OF HYPERTENSION (FHBP) IS ASSOCIATED WITH RENAL VASCULAR LESIONS (RVL) AND PROGRESSION OF THE DISEASE IN IGA NEPHROPATHY (IgAN).

Rehouni BOULAHROUZ, C. Stanescu, C. Charasse, KS. Ang, Ph. Le Cacheux, F. Léonetti, N. Rioux *, M.P. Ramée *, P. Simon. Service de Néphrologie, CH St Brieuc et *Laboratoire d'Anatomopathologie B, CHU Rennes.

ASSOCIATION BETWEEN METABOLIC SYNDROME AND THE PROGRESSION IN IgA NEPHROPATHY (IgAN).

Tibor VAS, Tibor KOVACS, Judit NAGY. Nephrological Center and 2 nd Dept. Of Medicine, Univ. Med. School of Pécs 7624 Pécs, Pacsirta u. 1, Hungary.

CLINICAL GUIDELINES OF IGA NEPHROPATHY IN JAPAN (2 ND VERSION).

Yasuhiko TOMINO and Hideto SAKAI. Special Study Group (IgA néphropathy) on Progressive Glomerular Disease, Ministry of Health, Labor and Welfare of Japan.

PROTEINURIA AT BASELINE AND DURING FOLLOW-UP AT RISK FACTORS FOR LONG-TERM OUTCOME IN A CHRONIC RENAL DISEASE : HENOCH-SCHOENLEIN PURPURA NEPHRITIS.

Rosanna COPPO, S. ANDRULLI°, B. GIANOGLIO, G. CONTIN, A. AMORE, on behalf of the Italian Group of Renal Immunopathology; Nefrologia, Dialisi Trapianti, Ospedale Regina Margherita, Piazza Polonia 94, 10126 Torino, Italy.

A RETROSPECTIVE ANALYSIS OF THE CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF IGA NEPHROPATHY WITH HEMATURIA AND/OR MINIMAL PROTEINURIA.

Hong ZHANG, JICHENG LV, YUQING CHEN, GANG LIU, HAIYAN WANG. Institute of Nephrology and Renal division of Peking University First Hospital, Peking University, Beijing, China.

UPDATE ON GENETICS IN FAMILIAL IGAN.

Ali GHARAVI (New York; USA)

TWO NOVEL LOCI EFFECTING THE DEVELOPMENT OF IgA NEPHROPATHY (IgAN): 4q22.1-31.21 AND 7q33-36.3.

Francesco P SCHENA 1, Giuseppina CERULLO 1, Diletta D. TORRES 1, Francesco SCOLARI 2, Marina FORAMITTI 2, Antonio AMOROSO 3, Doroti PIRULLI 3, Jürgen FLOEGE 4, Peter R. MERTENS 4*, Klaus ZERRES 4, Efstathios ALEXOPOULOS 5, Dimitrios KIRMIZIS 5, Leopoldo ZELANTE 6, Luigi BISCEGLIA 8, Michele DI PERNA 8, E MAZZUCCO 8 on behalf of the European IgAN Consortium. 1 Renal Unit, University of Bari, Italy; 2 Renal Unit, Spedali Civili, Brescia, Italy; 3 Genetic Unit, University of Trieste, Italy; 4 Division of Nephrology and Immunology, 4* Institute of Human Genetics, University of Aachen, Germany; 5 Renal Unit, Aristotelian University of Thessaloniki, Greece; 6 Genetic Unit, IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.

SIGNIFICANT INFLUENCE OF CCR5 GENE POLYMORPHISM ON PROGRESSION IN IgA NEPHROPATHY (IGAN).

François BERTHOUX, Patricia Berthoux, Marie-Thérèse Linossier, Lise Thibaudin, Ulf Panzer, Rolf Stahl. Nephrology Department, University North Hospital, 42055 Saint-Etienne Cédex 2, France.

SERUM PARAOXONASE ACTIVITY AND ITS GENE POLYMORPHISM IN IGA NEPHROPATHY WITH OR WITHOUT PROGRESSION.

Tibor KOVACS 1,2, Tibor VAS 1, Ildiko SERES 3, Tamas SZELESTEI 1, Shelley HARRIS 2, Colin SHORT 2, Istvan WITTMANN 1, György PARAGH 3, Paul BRENCHLEY 2, Judit NAGY 1. 1: 2 nd Dept of Medicine and Nephrological Centre, University of Pécs, Pécs, Hungary; 2: Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Manchester, United Kingdom; 3: 1 st Department of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary.

RELATIONSHIP BETWEEN Fc GAMMA RECEPTOR (Fc g R) POLYMORPHISM AND SEVERITY IN PATIENTS WITH IgA NEPHROPATHY.

Yuichi TANAKA 1, Toshinao Tsuge 1,2, Yusuke Suzuki 1, Satoshi Horikosi 1, Yutaka Kanamaru 1,2, Renato C. Monteiro 2 , Yasuhiko Tomino 1. 1. Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine; 2. Department of immunopathology, Bichat Medical School Inserm E0225, Paris, France.

ASSOCIATION OF 13-CA REPEAT ALLELE OF IFN g INTRON 1 POLYMORPHISM WITH DEVELOPMENT OF IgA NEPHROPATHY: A FAMILY-BASED STUDY.

Francesco P SCHENA 1, Giuseppina CERULLO 1, Diletta D. TORRES 1, Francesco SCOLARI 2, Marina FORAMITTI 2, Antonio AMOROSO 3, Doroti PIRULLI 3, Jürgen FLOEGE' 4, Peter R MERTENS 4, Klaus ZERRES 4*, Efstathios ALEXOPOULOS 5, Dimitrios KIRMIZIS 5, Leopoldo ZELANTE 6, Luigi BISCEGLIA 6, on behalf of the European IgAN Consortium. 1 Renal Unit, University of Bari, Italy; 2 Renal Unit, Spedali Civili, Brescia, Italy; 3 Genetic Unit, University of Trieste, Italy; 4 Division of Nephrology and Immunology, 4* Institute of Human Genetics, University of Aachen, Germany; 5 Renal Unit, Aristotelian University of Thessaloniki, Greece; 6 Genetic Unit, IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.

INFLUENCE OF CYTOKINE GENE POLYMORPHISMS ON THE PROGRESSION OF IGA NEPHROPATHY.

Christos BANTIS, K. IVENS, S. AKER, N. KLEIN-VEHNE, B. GRABENSEE, P. HEERING. Department of Nephrology and Rhematology, Heinrich-Heine University of Düsseldorf, Mooerenstr. 5, 40225 Düsseldorf, Germany.

TO CAST OUT THE NINES: DETECTION OF ABERRANTLY GLYCOSYLATED IgA IN A FAMILIAR CLUSTERING OF IgA NEPHROPATHY (IgAN).

Marina FORAMITTI*, F. SCOLARI*, P. CIRINA § , Alessandro AMORE ! , R. COPPO § . Nephrology, Dialysis and Transplantation Units of Brescia* and Turin § , Italy.

INCREASED SYNTHESIS OF INTERLEUKIN-6 IN HUMAN RENAL TUBULAR EPITHELIAL CELL CULTURED WITH SPENT MEDIUM FROM IgA-PRIMED HUMAN MESANGIAL CELL.

Loretta Y.Y. CHAN, Joseph C.K. LEUNG, Anita W.L. TSANG, Sydney TANG, Kar NENG LAI. Departments of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

IMMUNOMODULATION OF A NOVEL FC a R EXPRESSED BY HUMAN MESANGIAL CELLS.

Karen MOLYNEUX, Alice C. SMITH, John FEEHALLY and Jonathan BARRATT. John Walls Renal Unit, Leicester General Hospital and Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

IgA1 O-GLYCOSYLATION PROFILING BY HIGH RESOLUTION MALDI-ToF-MASS SPECTROMETRY.

Edward TARELLI, S. POURIA*, P. CORRAN*, A. SMITH + , H. SMITH + , S. CHALLACOMBE*, B. HENDRY*. St George's Hospital Medical School, *University of London and + University of Leicester, U.K.

OVERPRODUCTION OF HYPOGLYCOSYLATED IGA1 DUE TO THE DISORDERED BALANCE OF IGA- AND IGG- PRODUCTION AND OF IGA1- AND IGA2- PRODUCTION IN THE TONSILLAR TISSUE OF IGA NEPHROPATHY PATIENT.

Akihiko ITOH *, Hitoo IWASE*, Toru TAKATANI*, Makito OKAMOTO*, Yoshiyuki HIKI**, Ikuko NAKAMURA # , Yutaka KOBAYASHI # . Kitasato University, Saganihara, Japan, **Fujita Health University, Toyoake, Japan, # Akebono Hospital, Machida, Japan.

SIMILARITY BETWEEN SERUM PROTEINS BINDING TO HYPOGLYCOSYLATED IGA1-SEPHAROSE AND THE SERUM PROTEINS INCLUDING IGA DEPOSITED IN GLOMERULI OF IGA NEPHROPATHY PATIENTS.

Toru TAKATANI*, Hitoo IWASE*, Akihiko ITOH*, Masaaki HIGASHIHARA*, Yoshiyuki HIKI**, Ikuko NAKAMURA # , Yutaka KOBAYASHI # . Kitasato University, Sagamihara, **Fujita Health University, Toyoake, # Akebono Hospital, Machida, Japan.

REGULATION OF THE EXPRESSION OF GLYCOSYLTRANSFERASES INVOLVED IN O-GLYCOSYLATION OF IgA1 HINGE REGION BY CYTOKINES.

Judit ANDRASI, Huong L. VU, Zina MOLDOVEANU, Stacy HALL, Rhubell BROWN, Milan TOMANA, Milan RASKA, Bruce A. JULIAN, Jan NOVAK, AND Jiri MESTECKY. University of Alabama at Birmingham, Birmingham, AL 35294, USA.

DETECTION OF EPSTEIN-BARR VIRUS DNA BY NESTED SEMIQUANTITATIVE REALTIME PCR IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH IgA NEPHROPATHY.

Huong L. VU 1, Huan H. NGUYNEN 1, Zina MOLDOVEANU 1, Judit ANDRASI 1, Jan NOVAK 1, Milan TOMANA 2, Bruce JULIAN 2, and Jiri MESTECKY 1. Departments of 1 Microbiology and 2 Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

INCREASED IL6 AND MCP1 URINARY EXCRETION CORRELATE TO HISTOLOGICAL FINDINGS IN IgA NEPHROPATHY.

Maria STANGOU, Efstathios ALEXOPOULOS, Ekaterini PAPAGIANNI, Spiros DOVAS, Dimitrios KIRMIZIS, Afroditi PANTZAKI*, Dimitrios MEMMOS. Nephrology and *Pathology Departments, Hippokration Hospital, Thessaloniki, Greece.

RELATIONSHIP BETWEEN LEVELS OF URINARY TYPE IV COLLAGEN AND RENAL IN PATIENTS WITH IgA NEPHROPATHY.

Hiroaki IO, Chieko HAMADA, Mitsumine FUKUI, Satoshi HORIKOSHI, Yasuhiko TOMINO. Division of Nephrology, Department of Internal Medicine, Juntendo Uniersity School of Medicine, Tokyo, Japan.

ALTERED TROPOMYOSIN PROTEIN EXPRESSION IN IMMUNOGLOBULIN A NEPHROPATHY PATIENTS.

Saeed AHMED 1, S.A. DUNN 1 and T.H. THOMAS 1, School of Clinical Medical Sciences, Newcastle University, Floor 4 William Leech building, Framlington place, Newcastle upon Tyne NE2 4HH, UK 1 .

THE INCIDENCE OF IGA NEPHROPATHY (IgA N) REMAINS STABLE AND IS SIMILAR WHATEVER THE AGE GROUPS.

Corina STANESCU, P. SIMON, R. BOULAHROUZ, C. CHARASSE, K.S. ANG, Ph. LE CACHEUX, F. LEONETTI, N. RIOUX*, M.P. RAMEE*, Service de Néphrologie, CH St Brieux et *Laboratoire d'Anatomopathologie B, CHU Rennes.

ACUTE RENAL FAILURE IN IGA NEPHROPATHY.

Gan LIU, Wanzhong ZOU, Haiyan WANG, Renal Department, First Hospital, Peking University, Beijing, China, 100034.

ASSOCIATION OF IgA NEPHROPATHY AND INFLUENZA A EPIDEMICS.

Ladislava GRCEVSKA, V. RISTOVSKA, S. DZIKOVA, M. POLENAKOVIC, M. KARANFILOVA. Department of Nephrology, Clinical Center Skopje and Public Health Institute, Skopje, R. Macedonia.

IGA NEPHROPATHY WITH NEPHROTIC RANGE PROTEINURIA.

Fernand M.M. LAI, C.C. SZETO, P.C.L. CHOI, K.M. CHOW, C.B. LEUNG, P.K.T. LI, K.F. TO. Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

UTEROGLOBIN GENE G38A POLYMORPHISM INFLUENCES SIGNIFICANTLY PROGRESSION BUT NOT INITIATION IN PRIMARY IgA NEPHROPATHY (IGAN).

Patricia BERTHOUX, Lise Thibaudin, Christophe Mariat, Valérie Bin, Alice Chanavat and François Berthoux. Nephrology Department, University North Hospital, 42055 Saint-Etienne Cédex 2, France.

VARIANTS OF SELECTIN GENES DO NOT INFLUENCE THE DEVELOPMENT OF IGA NEPHROPATHY IN HUNGARIAN PATIENTS.

Tamas SZELESTEI, Tibor KOVACS, Ghosh MEENAKSHI, Tibor VAS, Judit NAGY. Nephrological Center and 2 nd Dept. of Medicine, Univ. Med. School of Pécs, 7624 Pécs, Pacsirta u. 1, Hungary.

MANNOSE-BINDING LECTIN (MBL) GENE POLYMORPHISM AT CODON 54 AND IgA NEPHROPATHY.

Patricia Berthoux, Lise THIBAUDIN, Marie-Thérèse Linossier , François Berthoux . Nephrology Department, University North Hospital, 42055 Saint-Etienne Cédex 2, France.

CYTOKINE GENE POLYMORPHISMS ASSOCIATE WITH SUSCEPTIBILITY TO AND SEVERITY OF IGA NEPHROPATHY IN SWEDISH POPULATION.

Iva GUNNARSSON, Sigrid LUNDBERG, L. WRAMNER, AM HYOTONEN, M. HAHN-ZORIC, PA WESTERBERG, J. AHLMEN, LA HANSON, Stefan H. JACOBSON, Leonid PADYUKOV. Division of Medicine, Karolinska Hospital, S-171 76 Stockhom, Sweden.

SEARCH FOR THE CANDIDATE GENE POLYMORPHISMS IMPLICATED IN THE PROGRESSION OF IGA NEPHROPATHY.

Miroslav MERTA, Jana REITEROVA, Dita KMENTOVA, Romana RYSAVA, Vladimir TESAR, Zuzana CABARTOVA*, Jitka STEKROVA*, Ondrej VIKLICKY**. Dept. of Nephrology, 1 st Faculty of Medicine, Charles Univ., Prague, CR. *Dept. of Molecular Genetics, 1 st Faculty of Medicine, Charles Univ., Prague, CR. **Institute of Clinical and Experimental Medicine, Prague, CR.

ELECTRON MICROSCOPY EXAMINATION IS ESSENTIAL IN THE DIAGNOSIS OF FAMILIAL IGA NEPHROPATHY.

Hong ZHANG, JICHENG LV, YUQING CHEN, GANG LIU, YOUKANG ZHANG, HAIYAN WANG. Institute of Nephrology and Renal Division of Peking University First Hospital, Peking University, Beijing, China.

FAMILIAL CLUSTERING OF DIFFERENT FORMS OF PRIMARY GLOMERULONEPHRITIS (GN) : VALTROMPIA STUDY.

Claudia IZZI, Marina FORAMITTI, Elisabetta PRATI, Battista Fabio VIOLA, Dini BELLERI, Adolfo REMEDIO, Luigi LEONE, Francesco SCOLARI. Division of Nephrology, Spedali Civili; Azienda Sanitaria Locale, Bescria, Italy.

SIGNIFICANT EFFECT OF TONSILLECTOMY AND ORAL STEROID THERAPY ON CLINICAL REMISSION IN PATIENTS WITH IgA NEPHROPATHY.

Makoto TOMITA, Yoshiyuki HIKI, Midori HASEGAWA, Yutaka KOBAYASHI*, Satoshi SUGIYAMA. Division of Nephrology, Department of Medicine, Fujita Health University, School of Medicine, 1-98 Dengakukakubo Kutstukake Toyoake Aichi, Japan, *Department of Medicine, Akebono Hospital, Tokyo, Japan.

GENETIC AND HUMORAL FACTORS IN RECURRENCE OF IgA NEPHROPATHY AFTER TRANSPLANTATION.

Rosanna COPPO, F. LOMBARDO, M. CHIESA, P. PASSERINI*, P. CIRINA, G. CONTI, A. TARANTINO*, R. GIRAUDI°, M. MESSINA°, G. SEGOLONI°, C. PONTICELLI*, A. AMORE. Nefrologia, Dialisi Trapianto, Ospedale Regina Margherita. Piazza Polonia 94, 10126 Torino, Italy. *Nefrologia, Dialisi, Trapianto, Policlinico Milano, Via Commenda, Italy. °Nefrologia, Dialisi Trapianto, Ospedale S. Giovanni Battista, Molinette, Corso Bramante, Università di Torino, Italy.

RECURRENCE OF IgA NEPHROPATHY AND HENOCH-SCHONLEIN PURPURA NEPHRITIS AFTER KIDNEY TRANSPLANTATION: MAIN RISK FACTORS.

Maria-José SOLER, J.M a PUIG, M. MIR, M.A. ORFILA, E. RODRIGUEZ, A. MUNNE*, S. VAZQUEZ, F. BARBOSA, J. LLOVERAS. Hospital del Mar, Department of Nephrology, Department of Pathology*. Passeig Maritim, 25-29 Barcelona (08003), Spain.

TREATMENT OF IGAN: WHAT IS NEW?

Ronald HOGG (Dallas; USA)

PROSPECTIVE TRIAL OF ORAL CORTICOSTEROID OR ANGIOTENSIN II (AII)-SUPPRESSION IN PATIENTS WITH NORMOTENSIVE IGA NEPHROPATHY: COMPARABLE RENOPROTECTIVE EFFECT THROUGH SUPPRESSING DIFFERENT CHEMOKINE PATHWAYS.

Hidetoshi KANAI, K. Masutani , R. Katafuchi , K. Tsuruya , H. Yotsueda , M. Taniguchi , M. Tokumoto , K. Hori , H. Kumagai , H. Hirakata , and M. lida . Depart. of Medicine & Clinical Sciences, Graduate School of Medical Science, Kuyshu Univ, Fukuoka, Japan.

MYCOPHENOLATE MOFETIL IN IgA NEPHROPATHY - RESULTS OF A THREE YEARS PROSPECTIVE PLACEBO-CONTROLLED RANDOMIZED STUDY.

Bart D. MAES *, Raymond Oyen § , Kathleen Claes *, Pieter evenepoel *, Dirk Kuypers *, Johan Vanwalleghem *, Boudewijn Van Damme + , and Yves F. Ch. Vanrenterghem . Department of Medicine, Division of Nephrology*, Department of Radiology § and Department of Pathology + , University Hospital Gasthuisberg, B-3000 Leuven, Belgium.

HONG KONG STUDY USING VALSARTAN IN IGA NEPHROPATHY (HKVIN) - A DOUBLE-BLIND RANDOMISED PLACEBO-CONTROLLED STUDY.

Philip K.T. LI, C.B. LEUNG, K.M. CHOW, Alex W. YU, Teresa Y.H. WONG, Mattew K.L. TONG, Andrew K.M. WONG, T.C. AU, Y.W. HO, C.C. SZETO for the HKVIN Study Group. Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong.

STEROIDS PLUS RAMIPRIL VERSUS RAMIPRIL ALONE IN THE TREATMENT OF IGA NEPHROPATHY: INTERIM ANALYSIS OF A PROSPECTIVE, CONTROLLED, RANDOMIZED, MULTICENTRIC TRIAL.

Diletta D. TORRES, Michele ROSSINI, Carlo MANNO, Loreto GESUALDO*, Giuseppe GRANDALIANO, Francesco P. SCHENA on behalf of the EPRAN Study Group. Department of Emergency and Organ Transplantation, Division of Nephrology, University of Bari, Italy; *Chair of Nephrology University of Foggia.

IGAN RECURRENCE AFTER RENAL TRANSPLANTATION.

Jürgen FLOEGE (Aachen; Germany)

RECURRENT IGA NEPHROPATHY AFTER TRANSPLANTATION DESPITE MYCOPHENOLATE MOFETIL IMMUNOSUPPRESSION.

Arun CHANDRAKANTAN, Catherine V. Barker, Bruce A. JULIAN. Division of Nephrology, 1530 Third Avenue South, University of Alabama at Birmingham, Birmingham, Alabama, 35294 USA.