RESEARCH CENTRES

 


University Hospital, Division of Nephrology, Department of Internal Medicine,
Juntendo University School of Medicine, Hospital Juntendo
Tokyo, Japan

 

 

Head of the Unit
Prof. Yasuhiko Tomino
Clinical Staff
 Associate Prof. : Satoshi Horikoshi.,
Assistant Prof.: Chieko Hamada, Mitsumine Fukui, Kunimi Maeda, Atsushi Kurusu, Hisaaki Rinno, Toshimasa Hishiki
Attending : Kyouichi Tashiro, Ichiyuu Shou, Takeshi Hayashi, Yukihiko Takeda, Tomohito Gohda, Hiroaki Io, Ayumi Shimizu
Research and Laboratory
 Drs.: Kenji Shiina, Michiro Wakabayashi, Michimasa Kobayashi, Tomohito Nishitani, Takahiro Yamanaka, Mitsuhiro Watanabe, Hitoshi Susuki, Yuuki Ro, Michifumi Yamashita, Hisatsugu Takahara, Yuuichi Tanaka, Mitsuo Tanimoto, Chiaki Tanifuji, Masanori Inaba, Shinji Hagiwara, Kisara Onda, Keiko Obayashi, Takamichi Ito and Tatsuya Kanou

 

CONTACTS  
E-Mail jin-01@med.juntendo.ac.jp
Fax +81-3-3813-1183, +81-5802-1065
Full postal address Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan
Website of the unit www.juntendo-jinzounaika.com

 

Research Interests
Clinical Research
Research Programs and Projects List:
• Treatment of IgA Nephropathy,

Basic research
Research Programs and Projects List
• Initiation of IgA Nephropathy
• Progression of IgA Nephropathy

Fellows program: Specify if the Unit accepts from other Countries for:
Short(1-2 month) well focused trained programs either clinically or laboratory oriented Yes
Long (at least 1 year) research fellowships Yes
Specify corresponding availability of grants No (Can be aided to apply)
Specify if the Unit may provide help for accommodation Yes

 

PUBLICATIONS LIST

Specific topics of research in IgAN

• Inhibition of proliferation of cultured mesangial cells (1)
• Inhibition of accumulation of extracellular matrix (2)
• Serum IgA/C3 ratio as a predictor factor for IgAN (2,7)
• IgAN in ddYmice:
   - effect of prednisolone loaded liposomes (3,12,16)
   - effect of dilazep (8,20,22)
   - effect of valsartan (9,19)
• Apoptosis :
   - apoptotic cells in renal biopsies (6)
   - apoptosis in cultured mesangial cells (21)
• Cystatin C and prognosis (10)
• Cytokines (11, 17)
• Podocyte injury and prognosis (13)
• Fc alpha receptor gene polymorphism (14,15)
• ACE gene polymorphism (17)

IgAN Publication List (2000-2003)

1. He JS, Horikoshi S, Funabiki K, Maeda A, Kobayashi M, Shirato I, Tomino Y: Inhibition of geranylgeranylation suppresses the proliferation of rat cultured mesangial cells. NEPHROLOGY 7 : 239-243, 2002 Article Link
2. Ishiguro C, Yaguchi Y, Funabiki K, Horikoshi S, Shirato I, Tomino Y: Serum IgA/C3 ratio may predict diagnosis and prognostic grading in patients with IgA nephropathy. Nephron 91 : 755-758, 2002 Pubmed Link
3. Liao J, Hayashi K, Horikoshi S, Ushijima H, Kimura J, Tomino Y: Prednisolone loaded liposome decreases the accumulation of glomerular extracellar matrix and glomerular injury of IgA nephropathy in ddY mice. Nephrology 7: 183-188, 2002 Article Link
4. Chen HC, Guh JY, Shin SJ, Tomino Y: Effect of pravastatin on superoxide and fibronectin production of mesangial cells induced by low-density.Kidney Blood Press Res 25: 2-6, 2002 Pubmed Link
5. He JS, Horikoshi S, Funabiki K, Shirato I, Tomino Y: Cerivastatin inhibits fertal calf serum-induced DNA synthesis in cultured rat mesangial cells. NEPHROLOGY 7: 83-86, 2002 Article Link
6. Tashiro K, Kodera S, Shou I, Kurusu A, Tomino Y: Apoptotic cells in six patients with IgA nephropathy in repeat biopsies. Nephrology, 6 : 93-98, 2001 Article Link
7. Tomino Y, Suzuki S, Imai H, Saito T, Kawamura T, Yorioka N, Harada T, Yasumoto Y, Kida H, Kobayashi Y, Endoh M, Sato H, Saito K . Measurement of serum lgA and C3 may predict the diagnosis of patients with lgA nephropathy prior to renal biopsy. J Clin Lab Anal. 14:220-223, 2001 Pubmed Link
8. Hayashi T, Kaneko S, Nguyen Tat Thang, Shou I, Shirato I, Tomino Y: Effect of dilazep hydrochloride on the immunohistopathology of lgA nephropathy in ddY mice. Nephron, 86:327-332, 2001 Pubmed Link
9. Suzuki Y, Nguyen Tat Thang, Horikoshi S, Shirato I, Nakamura S, Kimura M,Tomino Y: Effect of valsartan, an angiotensin II AT1receptor blocker, on the glomerular fibrosis of IgA nephropathy in ddY mice. Nephron , 86:374-375, 2001 Pubmed Link
10. Tomino Y,Suzuki Y, Gohda T, Kobayashi M, Horikoshi S, Imai H, Saito K: Serum cystatin C may predict the prognotic stages of patients with IgA nepheropathyprior to biopsy. J Clin Lab Anal, 15: 25-29, 2001 Pubmed Link
11. Huang F, Horikoshi S, Kursu A, Shibata T, Suzuki S, Funabiki K, Shirato I, Tomino Y: Urinary levels of interleukin-8(IL-8) and disease activity in patients with IgA nephropathy. J Clin Lab Anal, 15:30-34,2001 Pubmed Link
12. Liao J, Hayashi K, Ushijima H, Kimura J, Tomino Y: Effect of steroid-liposome on immunohistopathology of IgA nephropathy in ddY mice. Nephron, 89: 194-200, 2001 Pubmed Link
13. Hishiki T, Shirato I, Takahashi Y, Funabiki K, Horikoshi S, Tomino Y: Podocyte injury predicts prognosis in patients with IgA nephropathy using a small amount of renal biopsy tissue.Kidney Blood Press Res. 24:99-104, 2001 Pubmed Link
14. Tsuge T, Shimokawa T, Horikoshi S, Tomino Y, Ra C: Polymorphism in promoter region of Fcalha receptor gene in patients with IgA nephropathy. Hum genet, 108: 128-133, 2001 Pubmed Link
15. Tomino Y: Association of gene polymorphism of polymeric immuno-globulin receptor and IgA nephropathy. Intenal Medicin, 40: 847-848, 2001 Pubmed Link
16. Tomino Y, Suzuki S, Imai E, et al.: Measurement of serum IgA and C3 may predict the diagnosis of patients with IgA nephropathy prior to renal biopsy. J Clin Lab Anal., 14 :220-223, 2000 Pubmed Link
17. Tomino Y, Tsuge T: Role of cytokine mediators in the pathogenesis of IgA nephropathy. Hong Kong  J Nephrol, 2 : 68-73, 2000 Article Link
18. Suzuki S, Suzuki Y, Kobayashi Y, Harada T, Kawamura T, Yoshida H, Tomino Y: Insertion/deletion polymophism in ACE gene is not associated with renal progression in Japanese patients with IgA nephropathy. Am J Kidney Dis, 35 : 869-903, 2000 Pubmed Link
19. Suzuki Y, Thang NT, Horikoshi S, Shirato I, Nakamura S, Kimura M, Tomino Y: Effect of valsaltan, an angiotensin II AT(1) receptor blocker, on the glomerular fibrosis of IgA nephropathy in ddY mice. Nephron, 85 : 374-375, 2000 Pubmed Link
20. Hayashi T, Kaneko S, Thang NT, Shirato I, Tomino Y: Effects of dilazep hydrochlorideon the immunohistopathology of IgA nephropathy in ddY mice. Nephron, 86: 327-332, 2000 Pubmed Link
21. Shike T, Tashiro K, Gohda T, Funabiki K, Shirato I, Tomino Y: Effect of calciumu chanel blockers, nifedipine and benidipine, on death of cultured mouse mesangial cells. Kidney Blood Press Res, 23 : 126-132, 2000 Pubmed Link
22. Gohda T, Makita Y, Shike T, Funabiki K, Horikoshi S, Shirato I, Tomino Y: Effect of dilazep hydrochloride, an antiplat elet agent, on the proliferation of cultured mouse glomerular mesangial cells. Nephron, 84: 90-91, 2000 Pubmed Link